Prime 95B Series | Low Noise sCMOS Camera

The Prime 95B is a high sensitivity sCMOS camera designed for unmatched performance, featuring backside illumination (BSI) technology—a groundbreaking first for scientific CMOS cameras. With an impressive quantum efficiency (QE) of up to 95%, the Prime 95B converts nearly all incident photons into measurable signals. Unlike microlens-based QE enhancements that lose effectiveness with higher magnification, the BSI sensor channels light directly into the pixel photodiode, bypassing structures that could absorb or reflect light.

Equipped with large 11 µm pixels, the Prime 95B captures over 300% more signal than standard sCMOS cameras at 100X magnification. It also surpasses EMCCD cameras by eliminating excess noise and the need for EM gain calibration, offering greater stability, cost-effectiveness, and longer sensor life.

With a true 16-bit dynamic range, the Prime 95B excels in capturing both faint and bright signals within the same image, delivering photon-noise-limited performance. Its exceptional sensitivity not only reveals weaker signals but also enables faster frame rates and reduced excitation intensity to minimize photodamage in live-cell imaging. Despite these advanced capabilities, the Prime 95B retains the high frame rates, wide field of view, and ultra-low read noise that make sCMOS cameras ideal for demanding applications.